The BRCA1 gene encodes a protein that contains 1,863 amino acids. This protein is involved in DNA repair and regulation of the cell cycle.
1. Define the term ‘opening reading frame’ (ORF).
2. If BRCA1 protein is made up of 1,863 amino acids, how many nucleotides make up the open reading frame for BRCA1?
3. The mature mRNA for BRCA1 is no longer (made up of more nucleotides) than the BRCA1 ORF. Explain what makes the mRNA longer than the ORF.
4. Define the term ‘gene’.